UPDATE 3pm: A Queensland Ambulance Service spokesperson has confirmed that a 15-year-old girl has died following a crash 15km south of Bowen.
The spokesperson said the girl had initially been trapped within one of the vehicles.
She was freed, however paramedics were unable to revive her.
Meanwhile a six-year-old girl, an eight-year-old girl and a 45-year-old woman have been taken to Bowen Hospital in a stable condition.
A Queensland Police Service spokesperson said the crash involved a car and a ute, with one vehicle rolling during the incident.
Police officers remain at the scene and are attempting to determine the cause of the crash.
One lane of the highway is now open.
Paramedics treating 5 people at 2-vehicle crash Bruce Hwy south of #Bowen. Helo on the way. Avoid area if possible - road is blocked.— Queensland Ambulance (@QldAmbulance) July 24, 2015
EARLIER: Helicopter tasked to Bruce Hwy crash south of Bowen
A HELICOPTER has been tasked to a two vehicle crash 15 kilometres south of Bowen.
Paramedics treating five people involved in the crash.
Police say the road is expected to be closed for about an hour.
Update your news preferences and get the latest news delivered to your inbox.